Art

J-GLOBAL ID：201902222822764655   Reference number：19A0077755

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation

代謝活性化を避けるために設計された新規ベンゾブロマロン誘導体の合成【JST・京大機械翻訳】

Author (14)： Ohe Tomoyuki (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Umezawa Ryutaro (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Kitagawara Yumina (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Yasuda Daisuke (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Takahashi Kyoko (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Nakamura Shigeo (Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo, Japan) ,  Abe Akiko (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan) ,  Sekine Shuichi (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan) ,  Ito Kousei (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan) ,  Okunushi Kentaro (Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan) ,  Morio Hanae (Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan) ,  Furihata Tomomi (Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan) ,  Anzai Naohiko (Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Japan) ,  Mashino Tadahiko (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 28  Issue： 23-24  Page： 3708-3711  Publication year： 2018 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We synthesized six novel BBR d...

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Thesaurus term： hepatic toxicity ,  *Mus musculus ,  hepatocyte ,  Safety ,  cytotoxicity ,  toxicity ,  urate transporter1 ,  inhibitory activity ,  urate transport ,  *Activation, Metabolic ,  *Myomorpha ,  nitrogen heterocyclic compound ,  urea compound ,  hydroxy compound
Semi thesaurus term： アゴニスト , 【Automatic Indexing@JST】

Author keywords (4)： Benzbromarone ,  Metabolic activation ,  Hepatotoxicity ,  URAT1

JST classification (1)： Basic research of other drugs acting on metabolism  (GW13060I)

Substance index (1)： Uric Acid

Terms in the title (4)： 代謝活性化 ,  設計 ,  ベンゾブロマロン ,  誘導体