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J-GLOBAL ID：202002226350759316   Reference number：20A1500496

Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing

銅アミンオキシダーゼの中性子結晶学はキノン補因子と異常なプロトン共有のケト/エノラート相互変換を明らかにする【JST・京大機械翻訳】

Author (19)： Murakawa Takeshi (Department of Biochemistry, Osaka Medical College, 569-8686 Takatsuki, Osaka, Japan) ,  Kurihara Kazuo (Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 319-1106 Tokai, Ibaraki, Japan) ,  Shoji Mitsuo (Center for Computational Sciences, University of Tsukuba, 305-8577 Tsukuba, Ibaraki, Japan) ,  Shoji Mitsuo (Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), 332-0012 Kawaguchi, Saitama, Japan) ,  Shibazaki Chie (Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 319-1106 Tokai, Ibaraki, Japan) ,  Sunami Tomoko (Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 319-1106 Tokai, Ibaraki, Japan) ,  Tamada Taro (Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 319-1106 Tokai, Ibaraki, Japan) ,  Yano Naomine (Frontier Research Center for Applied Atomic Sciences, Ibaraki University, 319-1106 Tokai, Ibaraki, Japan) ,  Yamada Taro (Frontier Research Center for Applied Atomic Sciences, Ibaraki University, 319-1106 Tokai, Ibaraki, Japan) ,  Kusaka Katsuhiro (Frontier Research Center for Applied Atomic Sciences, Ibaraki University, 319-1106 Tokai, Ibaraki, Japan) ,  Suzuki Mamoru (Institute for Protein Research, Osaka University, 565-0871 Suita, Osaka, Japan) ,  Shigeta Yasuteru (Center for Computational Sciences, University of Tsukuba, 305-8577 Tsukuba, Ibaraki, Japan) ,  Kuroki Ryota (Quantum Beam Science Center, Japan Atomic Energy Agency, 319-1195 Tokai, Ibaraki, Japan) ,  Hayashi Hideyuki (Department of Chemistry, Osaka Medical College, 569-8686 Takatsuki, Osaka, Japan) ,  Yano Takato (Department of Biochemistry, Osaka Medical College, 569-8686 Takatsuki, Osaka, Japan) ,  Tanizawa Katsuyuki (Institute of Scientific and Industrial Research, Osaka University, 567-0047 Ibaraki, Osaka, Japan) ,  Adachi Motoyasu (Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 319-1106 Tokai, Ibaraki, Japan) ,  Okajima Toshihide (Department of Chemistry, Osaka Medical College, 569-8686 Takatsuki, Osaka, Japan) ,  Okajima Toshihide (Institute of Scientific and Industrial Research, Osaka University, 567-0047 Ibaraki, Osaka, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 20  Page： 10818-10824  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Recent advances in neutron cry...

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Thesaurus term： crystal structure ,  *proton ,  *Copper ,  protonation ,  *quinone ,  enzyme reaction ,  *diamine oxidase ,  Proteins ,  active site ,  *Crystallography ,  oxidation-reduction reaction ,  *cofactor ,  deprotonation ,  copper ion ,  histidine residue

Author keywords (5)： copper amine oxidase ,  neutron crystallography ,  proton sharing ,  quinone cofactor ,  metal-induced deprotonation

JST classification (2)： Enzyme in general  (EB09010D) ,  Molecular structure  (EB03020Y)

Terms in the title (9)： 銅アミンオキシダーゼ ,  中性子 ,  結晶学 ,  キノン ,  補因子 ,  プロトン ,  共有 ,  エノラート ,  相互変換