Art

J-GLOBAL ID：202102220117554446   Reference number：21A0293665

Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells

ミコフェノール酸モフェチルの活性型であるミコフェノール酸は形質細胞様樹状細胞によるIRF7核転座とI型IFN産生を妨害する【JST・京大機械翻訳】

Author (13)： Shigesaka Minoru (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Ito Tomoki (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Inaba Muneo (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Imai Kai (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Yamanaka Hideki (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Azuma Yoshiko (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Tanaka Akihiro (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Amuro Hideki (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Nishizawa Tohru (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Son Yonsu (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Satake Atsushi (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Ozaki Yoshio (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan) ,  Nomura Shosaku (First Department of Internal Medicine, Kansai Medical University, Hirakata City, Japan)
Material： Arthritis Research & Therapy (Web)
Volume： 22  Issue： 1  Page： 1-11  Publication year： 2020 
JST Material Number： U7412A  ISSN： 1478-6362  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Both humoral and cellular immu...

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Thesaurus term： serum ,  bone marrow ,  nausea ,  human(primates) ,  autoimmunity ,  T cell ,  flow cytometry ,  *translocation(genetics) ,  targeting ,  apoptosis ,  pathogenesis ,  Toll like receptor ,  nitrogen heterocyclic compound ,  lactone ,  phenolic compound ,  olefin compound ,  unsaturated carboxylic acid ,  phenol ether ,  polynuclear aromatic compound ,  carboxylate(ester)
Semi thesaurus term： インターロイキン12 ,  CD86抗原 , 【Automatic Indexing@JST】

Author keywords (6)： SLE ,  Plasmacytoid DCs ,  Myeloid DCs ,  Type I IFN ,  MPA ,  IRF7

JST classification (2)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Immunological reaction in general  (ED03010T)

Substance index (1)： Mofetil mycophenolate

Reference (43)：

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• Drugs.; Mycophenolate mofetil. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation; B Fulton, A Markham; 51; 2; 1996; 278-298; 10.2165/00003495-199651020-00007; citation_id=CR2
• Transplantation.; Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection; AC Allison, EM Eugui; 80; 2 Suppl; 2005; S181-S190; 10.1097/01.tp.0000186390.10150.66; citation_id=CR3
• Transplantation.; Synergistic effects of mycophenolate mofetil and sirolimus in prevention of acute heart, pancreas, and kidney allograft rejection and in reversal of ongoing heart allograft rejection in the rat; MD Vu, S Qi, D Xu, J Wu, J Peng, P Daloze; 66; 12; 1998; 1575-1580; 10.1097/00007890-199812270-00002; citation_id=CR4
• J Am Soc Nephrol; Attenuation of murine lupus nephritis by mycophenolate mofetil; MC Bruggen, B Walgreen, TP Rijke, JH Berden; 9; 8; 1998; 1407-1415; citation_id=CR5

Terms in the title (9)： ミコフェノール酸モフェチル ,  活性 ,  ミコフェノール酸 ,  形質細胞様樹状細胞 ,  IRF7 ,  核 ,  転座 ,  IFN ,  妨害