AKAISHI TATSUHIRO

アカイシタツヒロ | AKAISHI TATSUHIRO

Affiliation and department：
Homepage URL (1)： https://www.musashino-u.ac.jp/research/laboratory/pharmacy/lab/yakuri.html

Research field (3)： Pharmacology , Neuroscience - general , Animals: biochemistry, physiology, behavioral science

Research keywords (5)：薬理学一般 , 生理学一般 , 神経化学・神経薬理学 , 神経科学一般 , 生物系薬学

Research theme for competitive and other funds (7)：

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Papers (27)：

Hiroki Furuie#, Yuka Kimura#, Tatsuhiro Akaishi#, Misa Yamada, Yoshiki Miyasaka, Akiyoshi Saitoh, Norihiro Shibuya, Akiko Watanabe, Naoki Kusunose, Tomoji Mashimo, et al. Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity. Scientific Reports. 2023. 13. 1
Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Abe. 3′,4′-Dihydroxyflavonol Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses of Microglial Cells by Suppressing AKT-mTOR and NF-κB Pathways. Biological and Pharmaceutical Bulletin. 2023. 46. 7. 914-920
Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Abe. 3′,4′,7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK-STAT1 Pathway. Biological and Pharmaceutical Bulletin. 2022. 45. 3. 301-308
Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Abe. The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways. Biological and Pharmaceutical Bulletin. 2020. 43. 1. 138-144
Tatsuhiro Akaishi, Kazuho Abe. CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia. European Journal of Pharmacology. 2018. 819. 190-197

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MISC (21)：

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Books (12)：

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Lectures and oral presentations (51)：

プロテアーゼ活性化受容体1遮断薬ボラパキサルは高食塩負荷による多発性硬化症の増悪を抑制する
(第150回日本薬理学会関東部会 2024)
3’,4’-Dihydroxyflavonolの神経炎症抑制作用におけるAKT-mTOR経路の関与
(第97回日本薬理学会年会 2023)
高食塩食の継続摂取は多発性硬化症の発症を促進する
(第149回日本薬理学会関東部会 2023)
3′,4′-DihydroxyflavonolはミクログリアのLPS誘発炎症応答を抑制する
(第67回日本薬学会関東支部大会 2023)
3’,4’,7-Trihydroxyflavoneの神経炎症抑制作用におけるJNK-STAT1経路の関与
(第96回日本薬理学会年会 2022)

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Education (4)：

2001 - 2004 Nihon University Graduate School, Division of Pharmaceutical Sciences
2000 - 2001 The University of Tokyo Faculty of Medicine
1998 - 2000 Nihon University Graduate School, Division of Pharmaceutical Sciences
- 1998 Nihon University Faculty of Pharmaceutical Science

Professional career (3)：

Work history (5)：

2022/09 - 現在武蔵野大学薬学部薬学研究所薬理学研究室准教授
2009/04 - 現在 Lecturer
2009/04/01 - 現在 Musashino University Faculty of Pharmacy, Department of Pharmaceutical Sciences
2007/05 - 2009/03 Assistant Professor
2004/04 - 2007/04 Research Assistant

Committee career (18)：

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Association Membership(s) (3)：

日本神経科学学会 , 日本薬学会 , 日本薬理学会

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