Rchr
J-GLOBAL ID:200901019095970134   Update date: Sep. 19, 2024

Murata Hitoshi

ムラタ ヒトシ | Murata Hitoshi
Affiliation and department:
Job title: Senior Assistant Professor
Homepage URL  (2): https://www.okayama-u.ac.jp/user/cellbiol/https://pxy-www.a.okayama-u.ac.jp/user/cellbiol/
Research field  (2): Functional biochemistry ,  Molecular biology
Research keywords  (11): Neurodegenerative disease ,  Parkinson's disease ,  ミトコンドリア ,  SARM1 ,  NAD ,  PINK1 ,  細胞生物学 ,  タンパク質工学 ,  Mitochondria ,  Cell Biology ,  Protein Engneering
Research theme for competitive and other funds  (13):
  • 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
  • 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
  • 2022 - 2025 軸索変性誘導分子SARM1の活性・分解制御によるパーキンソン病治療法の開発
  • 2020 - 2023 新規S100A8/A9阻害分子の発見に基づいたがん脳指向転移の機構解明とその制御
  • 2019 - 2022 ミトコンドリア呼吸阻害による軸索変性誘導機構の解明とパーキンソン病への展開
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Papers (64):
  • Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. Correction: S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In vitro cellular & developmental biology. Animal. 2024
  • Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In vitro cellular & developmental biology. Animal. 2024
  • Fan Jiang, Youyi Chen, Nahoko Tomonobu, Rie Kinoshita, Ni Luh Gede, Yoni Komalasari, Carlos Ichiro, Kasano-Camones, Kazumi Ninomiya, Hitoshi Murata, et al. Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis. Front. Oncol. Sec. Molecular and Cellular Oncology. 2024. 14. 1371307
  • Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, et al. Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface. Frontiers in Oncology. 2024. 14
  • Hitoshi Murata, May Tha Zin Phoo, Toshiki Ochi, Nahoko Tomonobu, Ken-Ichi Yamamoto, Rie Kinoshita, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanuma, Masakiyo Sakaguchi. Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration. Journal of biochemistry. 2023
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MISC (41):
  • 合原勇馬, 友信奈保子, 木下理恵, 山本建一, 村田等, 阪口政清. Nuclear PD-L1 facilitates disseminative activity by suppressing Protein X in triple-negative breast cancer cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 合原勇馬, 友信奈保子, 木下理恵, 村田等, 山本健一, 難波正義, 許南浩, 公文裕己, 阪口政清. A novel function of REIC protein on tumor suppression through the downregulation of PD-L1 on cancer cells. 組織培養研究(Web). 2023. 41. 2
  • 山本健一, 平林大輔, 丸山顕嘉, 友信奈保子, 木下理恵, KOMALASARI Ni Luh Gade Yoni, 村田等, 合原勇馬, 江帆, 山内明, et al. The Zn2+-bound form of ZEB1 plays a crucial part in the promotion of invasiveness in breast cancer cells. 組織培養研究(Web). 2023. 41. 2
  • 友信奈保子, 木下理恵, 合原勇馬, KOMALASARI Ni Luh Gede Yoni, JIANG Fan, 村田等, 山本健一, 山内明, 近藤英作, 豊岡伸一, et al. HRG suppresses the S100A8/A9-mediated metastasis of melanoma cells. 組織培養研究(Web). 2023. 41. 2
  • 高橋徹多, 友信奈保子, KOMALASARI Ni Luh Gede Yoni, 合原勇馬, 山本健一, 木下理恵, 村田等, 阪口政清. Discovery of the mechanism of breast cancer progression focusing on cell-surface annexin A2/S100A11 binding. 組織培養研究(Web). 2023. 41. 2
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Patents (6):
Lectures and oral presentations  (77):
  • REIC/Dkk-3の受容体への結合はトリプルネガティブ乳がんのPD-L1の発現を抑制する
    (第45回 日本分子生物学会年会 2022)
  • 神経軸索変性メカニズムの解明と創薬への応用
    (第37回 創薬・薬理フォーラム岡山 2022)
  • REIC protein suppresses tumor progression through PD-L1 regulation in cancer cells
    (日本組織培養学会 第94回大会 2022)
  • Lysyl oxidase-like 4 is prominent in breast cancer progression through its en]ymatic activities
    (2022)
  • 炎症性疾患に対する抗S100A8/A9抗体療法におけるマクロファージの役割
    (日本組織培養学会 第94回大会 2022)
more...
Education (3):
  • - 2008 Okayama University The Graduate School of Natural Science and Technology (Doctor Course) Division of Chemistry and Biochemistry
  • - 2005 Okayama University The Graduate School of Natural Science and Technology
  • - 2003 Okayama University Faculty of Engineering Department of Bioscience and Biotechnology
Professional career (2):
  • 工学(博士) (岡山大学)
  • 工学(修士) (岡山大学)
Work history (3):
  • 2016 - 現在 岡山大学 大学院医歯薬学総合研究科 講師
  • 2010 - 2016 岡山大学 大学院医歯薬学総合研究科 助教
  • 2008 - 2010 岡山大学 大学院医歯薬学総合研究科 特任助教
Awards (6):
  • 2016 - 日本分子生物学会年会優秀ポスター賞
  • 2013 - 岡山医学会賞(結城賞)
  • 2009 - 日本組織培養学会奨励賞
  • 2007 - 岡山大学大学院自然科学研究科長賞
  • 2005 - 岡山大学ベンチャー・ビジネス・ラボラトリー研究企画賞
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Association Membership(s) (4):
THE JAPANESE TISSUE CULTURE ASSOCIATION ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPAN NEUROSCIENCE SOCIETY
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