Rchr
J-GLOBAL ID：200901028128469966
Update date: Aug. 23, 2023
Akamatsu Miki
アカマツ ミキ | Akamatsu Miki
Affiliation and department：
Job title：
Associate Professor,Associate Professor
Homepage URL (1)：
http://www.fsao.kais.kyoto-u.ac.jp/cgi-bin/cas/wiki.cgi?page=%C0%D6%BE%BE%A1%A1%C8%FE%B5%AA
Research field (4)：
Pharmaceuticals - chemistry and drug development
, Bioorganic chemistry
, Molecular biochemistry
, Environmental dynamics
Research keywords (11)：
排泄
, 膜透過
, 代謝
, 医農薬
, 構造活性相関
, 環境動態
, environment
, agrochemicals
, relationships
, structure-activity
, ADME
Research theme for competitive and other funds (8)：
- 2002 - タイにおける農薬の動態解析
- 2002 - Enviromental behavior of pesticides in Thailand
- 内分泌かく乱物質の構造活性相関に関する研究
- 農薬・医薬の構造活性相関に関する研究
- ペプチドの構造活性相関に関する研究
- Study on structure-activity relationship of endocrine disruptors
- Study on structure-activity relationship of pesticides and pharmaceuticals
- Study on Structure-Activity Relationship of Peptides
Show all
Papers (110)：
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Mori, S, Akamatsu, M, Fukui,, H, Tsukioka, J, Goto, K, Hirai, N. The unusual conformational preference of N1,N5,N10-tri-p-coumaroylspermidine E-Z isomers from the Japanese apricot tree for the (ZZZ)-form. Phytochem. Lett. 2019. 31. 131-139
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Ken-ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu. Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport. BIOORGANIC & MEDICINAL CHEMISTRY. 2016. 24. 14. 3184-3191
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Ken-ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu. In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines. TOXICOLOGY AND APPLIED PHARMACOLOGY. 2016. 298. 40-47
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Naoki Shirotani, Moe Togawa, Shinichi Ikushiro, Toshiyuki Sakaki, Toshiyuki Harada, Hisashi Miyagawa, Masayoshi Matsui, Hirohisa Nagahori, Kazuki Mikata, Kazuhiko Nishioka, et al. Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19. BIOORGANIC & MEDICINAL CHEMISTRY. 2015. 23. 20. 6594-6601
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Hikaru Nagaoka, Hisashi Nishiwaki, Takuya Kubo, Miki Akamatsu, Satoshi Yamauchi, Yoshihiro Shuto. Docking model of the nicotinic acetylcholine receptor and nitromethylene neonicotinoid derivatives with a longer chiral substituent and their biological activities. BIOORGANIC & MEDICINAL CHEMISTRY. 2015. 23. 4. 759-769
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MISC (17)：
Books (18)：
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農薬の構造活性相関研究-新規農薬の創製を目指して
シーエムシー出版 2018
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The GABA Antagonist γ-Benzene Hexachloride and its Polychlorinated Cyclohexane Analogs
American Chemical Society, Washington, DC 2017
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創薬動態,Classical および三次元構造活性相関手法による薬物動態解析(共著)
日本薬物動態学会,315-319 2006
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Effect of the phenyl ring modification on the antitumor activity of anti-microtubule agent dehydrophenylahistin.
2005
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Evaluation of estrogen receptor binding affinity of DDT-related compounds and their metabolites.
Environmental Fate and Safety Management of Agrochemicals,pp. 159-166 2005
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Lectures and oral presentations (7)：
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Possibility of in silico prediction of drug metabolites by major human Cytochrome P450 enzymes
(EuroQSAR2018 2018)
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In Silico prediction of pesticide metabolites by several human Cytochrome P450 enzymes - a case of tebufenozide derivatives
(The 11th China-Japan Joint Symposium on Drug Design and Development 2018)
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多様なヒトCYPによる農薬の代謝物予測-テブフェノジド類縁体を例として
(日本農薬学会2017 2017)
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RELATIONSHIPS BETWEEN STRUCTURES OF TEBUFENOZIDE DERIVATIVES AND THEIR INHIBITORY EFFECT ON QUINIDINE TRANSPORT BY P-GLYCOPROTEIN
(EuroQSAR2014 2014)
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Substrate Recognition by P-Glycoprotein, A Drug Efflux Pump, Based on Structure-ATPase Activity Relationships and Docking Studies
(The 9th China-Japan Joint Symposium on Drug Design and Development 2012)
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Works (6)：
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高感度質量分析計の開発と内分泌かく乱物質の分析
2000 - 2004
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Development of high-resolution Mass spectrometer and analysis of endocrine disruptors
2000 - 2004
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P-糖たんぱく質基質の構造活性相関研究
2004 -
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内分泌かく乱化学物質の構造活性相関研究
2004 -
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Relationship between chemical structures and activity of P-glycoprotein substrates
2004 -
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Education (4)：
- - 1977 Kyoto University Faculty of Agriculture
- - 1977 Kyoto University Faculty of Agriculture Agricultural Chemistry.
- Kyoto University
- Kyoto University Graduate School, Division of Agriculture Agricultural Chemistry
Professional career (1)：
- Doctor of Agricultural Science (Kyoto University)
Work history (4)：
- 1990 - 1996 Kyoto University Faculty of Agriculture
- 1990 - 1996 Kyoto University, Faculty of Agriculture, Instructor.
- 1978 - 1990 Kyoto University Faculty of Agriculture
- 1978 - 1990 Kyoto University, Faculty of Agriculture, research assistant.
Awards (2)：
- 2002 - 日本農薬学会業績賞(研究)
- 2002 - Pesticide science Society of Japan, Society Awards (on prominent achievment)
Association Membership(s) (6)：
アメリカ化学会
, 日本薬学会
, 日本ペプチド学会
, 日本農薬学会
, 日本農芸化学会
, American Chemical Society
