2017 - 2020 Screening of the food molecules to control incretin-signalin with novel mode of action
2014 - 2017 Study on the dietary components which affect incretin secresion by regulating the function of plasma membrane in enteroendocrine cells
2011 - 2013 Study on the role of ceramide kinase in the macrophage-function
2009 - 2010 Study on a regulation system of cellular functions in adiposities by sphingolipids.
2006 - 2007 Biological functions of Sphingolipids and their relevance to pathological phenomena
2005 - 2007 神経細胞におけるセラミドキナーゼの役割
2007 - 細胞膜スフィンゴ脂質と代謝性疾患に関する研究
2005 - スフィンゴ脂質の生理機能を応用した機能性食品開発
2000 - 2004 スフィンゴシン1-リン酸とその受容体の情報伝達機構と生理機能の解析
2001 - 2003 Molecular Mechanism of production and secretion of platelet-derived bioactive lysolipids
2003 - I型アレルギーとスフィンゴ脂質に関する研究
2001 - 免疫細胞におけるスフィンゴ脂質の役割
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Papers (123):
Yoichiro Hama, Emi Yamagata, Noriko Takahama, Yuka Yoshimura, Rin Yanagida, Susumu Mitsutake. Liberation of eicosapentaenoic acid and degradation of the major cell wall polysaccharide porphyran by fermentation of nori, the dried thalli of Pyropia yezoensis, with koji. Journal of Applied Phycology. 2021. 33. 6. 4105-4111
Tomotaka Nagasawa, Masaki Horitani, Shin ichi Kawaguchi, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake. The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids. FEBS Open Bio. 2021. 11. 11. 3081-3089
Tomotaka Nagasawa, Kanji Ishimaru, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake. Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion. Food and Function. 2020. 11. 12. 10534-10541