Tsunoda Shin-ichi

ツノダシンイチ | Tsunoda Shin-ichi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

国立研究開発法人医薬基盤・健康・栄養研究所客員研究員

Research field (1)： Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (23)：

2022 - 2025 2型TNF受容体を介する免疫制御機構の解明とがん免疫療法への応用
2021 - 2024 免疫難病治療の新規モダリティを目指したTNFR1シグナル選択的阻害薬の創製
2020 - 2023 浮遊粒子状物質によるインフラマソーム活性化におけるレドックス制御の仕組みの解明
2018 - 2021 Molecular design of immunocytokines for control of regulatory T cell function
2018 - 2021 Study of TNFR2-APP3 signaling pathway and and its immuno-suppressive function

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Papers (123)：

Masaki Inoue, Kanako Yamashita, Yuta Tsuji, Midori Miki, Shota Amano, Taichi Okumura, Koki Kuge, Takao Tone, Shota Enomoto, Chinatsu Yoshimine, et al. Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander. The Journal of Immunology. 2021. 206. 8. 1740-1751
Higashisaka K, Nakashima A, Iwahara Y, Aoki A, Nakayama M, Yanagihara I, Lin Y, Nagano K, Tsunoda SI, Saito S, et al. Neutrophil Depletion Exacerbates Pregnancy Complications, Including Placental Damage, Induced by Silica Nanoparticles in Mice. Frontiers in immunology. 2018. 9. 1850
Takashi Nagano, Kazuya Nagano, Hiromi Nabeshi, Tokuyuki Yoshida, Haruhiko Kamada, Shin-ichi Tsunoda, Jian-Qing Gao, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi. Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2017. 40. 5. 726-728
Masaki Inoue, Daisuke Ando, Haruhiko Kamada, Shintaro Taki, Mayumi Niiyama, Yohei Mukai, Takashi Tadokoro, Katsumi Maenaka, Taisuke Nakayama, Yuji Kado, et al. A trimeric structural fusion of an antagonistic tumor necrosis factor-alpha mutant enhances molecular stability and enables facile modification. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 16. 6438-6451
Takayuki Handa, Toshiro Hirai, Natsumi Izumi, Shun-ichi Eto, Shin-ichi Tsunoda, Kazuya Nagano, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi. Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice. NANOTECHNOLOGY. 2017. 28. 13. 135101

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MISC (45)：

T. Mori, K. Nagano, K. Higashisaka, Y. Yoshioka, H. Kamada, S. Tsunoda, Y. Tsutsumi. Optimization of an immune method to shorten time for inducing antibodies in mice. MOLECULAR BIOLOGY OF THE CELL. 2015. 26
Toshiro Hirai, Yasuo Yoshioka, Ko-ichi Ichihashi, Takahide Mori, Nobuo Nishijima, Takayuki Handa, Hideki Takahashi, Shin-ichi Tsunoda, Kazuma Higashisaka, Yasuo Tsutsumi. Silver nanoparticles induce silver nanoparticle-specific allergic responses. JOURNAL OF IMMUNOLOGY. 2014. 192
Yasuo Yoshioka, Asako Udaka, Toshiro Hirai, Hisae Aoshima, Ken Kokubo, Takumi Oshima, Tomoyuki Ohe, Tadahiko Mashino, Shin-ichi Tsunoda, Kazuma Higashisaka, et al. Fullerene C60 derivatives suppress the acquired immune responses. JOURNAL OF IMMUNOLOGY. 2014. 192
Kazuki Misato, Yasuo Yoshioka, Miyuki Uji, Asako Udaka, Takahide Mori, Manami Yamaguchi, Toshiro Hirai, Tokuyuki Yoshida, Hiromi Nabeshi, Tomoaki Yoshikawa, et al. The effects of oral administration of silica nanoparticles on immunologic response to the food antigen. JOURNAL OF IMMUNOLOGY. 2013. 190
Hideki Takahashi, Yasuo Yoshioka, Toshiro Hirai, Ko-ichi Ichihashi, Nobuo Nishijima, Tokuyuki Yoshida, Hiromi Nabeshi, Tomoaki Yoshikawa, Shin-ichi Tsunoda, Kazuma Higashisaka, et al. The size effects of amorphous silica nanoparticles on atopic dermatitis-like skin lesion. JOURNAL OF IMMUNOLOGY. 2013. 190

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