Research theme for competitive and other funds (13)：
2018 - 2021 Novel therapeutic approaches for treatment of myeloproliferative neoplasms based on aging control
2014 - 2017 Analysis of the role of circadian clock gene in leukemogenesis
2008 - 2010 Investigation of the mechanism of pancreatic beta-cell death underlying progressive nature of type 2 diabetes mellitus, aiming at the development of treatment strategy for the disease condition.
2006 - 2007 Investigation of insulin resistance-induced endoplasmic reticulum stress in the pancreatic β-cell and development of diabetes mellitus
2006 - 2007 Analysis of unfolded protein response in hematological malignancy
2004 - 2005 Molecular Pathophysiology of Wolfram Syndrome and Endoplasmic Reticulum Stress-associated Pancreatic β-cell Failure.
2003 - 2004 Analysis of MEKK1 involved in cytoskeleton and cell migration.
2002 - 2003 Investigation of the roles of WFS1 and glutamate dehydorogenase on the pancreatic β-cell function and regulation of insulin secretion
2001 - 2002 Studies on mechanisms of insulin-stimulated glucose transport : analysis of downstream signaling and real-time monitoring of GLUT4 translocation
2001 - 2002 Analysis of new binding proteins on N-terminal lesion of MEKK2,3,4
2000 - 2002 Generation of Wolfram syndrome mice, aiming at development of new therapeutics for diabetes through preserving pancreatic beta cells
2000 - 2001 NFkB経路および細胞死におけるMEKKinase1(MEKK1)の解析
2000 - 2001 In vitro induction of pancreatic β-cell development from mouse embryonic stem cells
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Papers (148)：
Yoshihiro Tokunaga, Yukinori Nakamura, Taishi Ando, Kensaku Katsuki, Kohei Sakai, Yuka Fujioka, Shota Nono, Takahiro Sasaki, Kaoru Yamamoto, Masaru Akiyama, et al. T-cell large granular lymphocytic leukemia with a STAT3 mutation successfully treated with cord blood transplantation. Internal medicine (Tokyo, Japan). 2024
Yoshihiro Tokunaga, Masaru Akiyama, Kohei Nakano, Kiminori Konaka, Akihiko Taguchi, Toshihiko Maeda, Ryota Sato, Takashi Kanda, Yukinori Nakamura, Toshiaki Yujiri, et al. Diffuse Large B-cell Lymphoma Complicated with Anti-3-hydroxy-3-methylglutaryl-Coenzyme A Reductase Immune-mediated Necrotizing Myopathy: A Case Report. Internal medicine (Tokyo, Japan). 2024
Usefulness of SARS-CoV-2 antigen quantitative assay. 2023. 72. 2. 205-209
Yuta Imai, Satomi Nagaya, Yuhei Araiso, Makiko Meguro-Horike, Tomoki Togashi, Kensho Ohmori, Yuka Makita, Eiichi Sato, Toshiaki Yujiri, Yuta Nagamori, et al. Identification and functional analysis of three novel genetic variants resulting in premature termination codons in three unrelated patients with hereditary antithrombin deficiency. International journal of hematology. 2022. 117. 4. 523-529
Yuji Okamoto, Mitsuhito Hirano, Kai Morino, Masashi K. Kajita, Shinji Nakaoka, Mayuko Tsuda, Kei-ji Sugimoto, Shigehisa Tamaki, Junichi Hisatake, Hisayuki Yokoyama, et al. Early Dynamics of Chronic Myeloid Leukemia on Nilotinib Predicts Deep Molecular Response. NPJ systems biology and applications. 2022. 8. 1. 39-39
1983 - 1989 Yamaguchi University Faculty of Medicine
Professional career (1)：
医学博士 (山口大学)
Work history (7)：
2018/04 - 現在 Yamaguchi University Graduate School of Medicine Department of Clinical Laboratory Science Professor
2011/04 - 2018/03 Yamaguchi University Graduate School of Medicine Associate Professor
2009/04 - 2011/03 YAMAGUCHI UNIVERSITY School of Medicine
2003/01 - 2009/03 山口大学医学部付属病院 第3内科 講師
2001/12 - 2002/12 Yamaguchi University School of Medicine
2000/04 - 2001/11 日本学術振興会 特別研究員(PD)
1996/07 - 1999/06 National Jewish Medical and Research Center Research Associate
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Committee career (2)：
2004/09 - 現在 日本血液学会 評議員
2004/06 - 現在 日本内科学会 中国地方会評議員
Awards (5)：
2013/05 - 山口大学霜仁会 学術振興賞本賞 藤生賞
2011/03 - 山口大学医学会 小西賞
2010/04 - (財)山口老年総合研究所 頴原賞
2008/06 - 日本白血病研究基金 一般賞
2004/03 - 山口大学医学会 中村賞
Association Membership(s) (10)：
American Society of Hematology
, 日本感染症学会
, 日本分子生物学会
, Japanese Society for Transplantation and Cellular Therapy
, 日本癌学会
, 日本内科学会
, 日本臨床腫瘍学会
, 日本血液学会
, 日本検査血液学会
, 日本輸血・細胞治療学会
