Rchr
J-GLOBAL ID：200901077054763078   Update date: Sep. 27, 2024

Isobe Masaharu

Isobe Masaharu
Affiliation and department：
University of Toyama

About University of Toyama


Job title： 教授
Homepage URL  (1)： http://enghp.eng.u-toyama.ac.jp/labs/lb01/
Research field  (2)： Medical biochemistry ,  Molecular biology
Research keywords  (6)： Therapeutic antibody ,  Antibody acquisition technology ,  記憶学習障害関連遺伝子 ,  白血病 ,  Human Genome Project ,  leukemia
Research theme for competitive and other funds  (25)：
  • 2021 - 2024 Elucidation of ligands of cancer-specific monomorphic major histocompatibility complexes and development of novel antibody therapies
  • 2015 - 2017 Development of the system for isolation of T-cell receptor like antibodies against tumor stem cells
  • 2013 - 2015 Development of methods for isolation of human monoclonal antibodies recognizing cancer stem cells
  • 2011 - 2012 Development and analysis of human monoclonal antibodies derived from patients with cancer
  • 2008 - 2010 Brain mechanisms underlying the anti-stress effects of green odor that is emanated from green leaves
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Papers (91)：
  • Kentarou Waki, Hideki Tani, Yumiko Saga, Takahisa Shimada, Emiko Yamazaki, Seiichi Koike, Okada Mana, Masaharu Isobe, Nobuyuki Kurosawa. Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein. 2023
  • Kengo Nishimura, Hiroaki Kitazawa, Takashi Kawahata, Kosuke Yuhara, Takahiro Masuya, Toshihiro Kuroita, Kentarou Waki, Seiichi Koike, Masaharu Isobe, Nobuyuki Kurosawa. The development of a highly sensitive and quantitative SARS-CoV-2 rapid antigen test applying newly developed monoclonal antibodies to an automated chemiluminescent flow-through membrane immunoassay device. BMC immunology. 2023. 24. 1. 34-34
  • Tatsuhiko Ozawa, Hideki Tani, Yuki Anraku, Shunsuke Kita, Emiko Igarashi, Yumiko Saga, Noriko Inasaki, Hitoshi Kawasuji, Hiroshi Yamada, so Ichiro Sasaki, et al. Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants. mAbs. 2022. 14. 1. e2072455
  • Maruf Mohammad Akbor, Juhyon Kim, Mai Nomura, Juno Sugioka, Nobuyuki Kurosawa, Masaharu Isobe. A candidate gene of Alzheimer diseases was mutated in senescence-accelerated mouse prone (SAMP) 8 mice. Biochemical and biophysical research communications. 2021. 572. 112-117
  • Maruf Mohammad Akbor, Nobuyuki Kurosawa, Masashi Tanaka, Masaharu Isobe. Polymorphic SERPINA3-R124C reduces pathogenesis of its wild type by shortening the lifetime of oligomeric Aβ. Bioscience, biotechnology, and biochemistry. 2021. 85. 8. 1861-1868
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MISC (138)：
  • 和氣 健太郎, 谷 英樹, 岡田 茉那, 磯部 正治, 黒澤 信幸. SARS-CoV-2スパイクタンパク質経鼻免疫マウス鼻粘膜組織由来モノクローナルIgA抗体の網羅的解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2T13a-01
  • 和氣 健太郎, 黒澤 信幸, 磯部 正治. SARS-COV2スパイクタンパク質の経鼻免疫で誘導されるマウス鼻腔粘膜由来IgAモノクローナル抗体取の特異性解析. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [3T15a-897)]
  • 和氣 健太郎, 黒澤 信幸, 磯部 正治. SARS-COV2スパイクタンパク質の経鼻免疫で誘導されるマウス鼻腔粘膜由来IgAモノクローナル抗体取の特異性解析. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-04)]
  • 仁井見 英樹, 小澤 龍彦, 谷 英樹, 岸 裕幸, 森永 芳智, 山本 善裕, 黒澤 信幸, 磯部 正治. 新型コロナウイルス検査のこれまでとこれから SARS-CoV-2変異株の流行とスーパー中和抗体の作出. 医療検査と自動化. 2021. 46. 4. 333-333
  • 仁井見英樹, 小澤龍彦, 谷英樹, 岸裕幸, 森永芳智, 山本善裕, 黒澤信幸, 磯部正治. SARS-CoV-2変異株の流行とスーパー中和抗体の作出. 医療検査と自動化(Web). 2021. 46. 4
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Patents (19)：
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Books (3)：
  • Genetic analysis of learning and memory deficits in SAMP8 mice.
    International Congress Series 1260 (Elsevier) 2004
  • Quantitative trait loci for age-related memory dysfunction in SAMP8 and JF1 mice.
    International Congress Series 1260 (Elsevier) 2004
  • 成人T細胞白血病とT細胞白血病における染色体異常の分子機構
    実験医学「ATLとAIDS」羊土社 1993
Lectures and oral presentations  (8)：
  • SARS-COV2スパイクタンパク質の経鼻免疫で誘導されるマウス鼻腔粘膜由来IgAモノクローナル抗体取の特異性解析
    (日本生化学会大会プログラム・講演要旨集 2021)
  • 新型コロナウイルス検査のこれまでとこれから SARS-CoV-2変異株の流行とスーパー中和抗体の作出
    (医療検査と自動化 2021)
  • A polymorphic form of SERPINA3 enhances neurotoxicity by prolonging the oligomeric state of amyloid β 42
    (日本分子生物学会年会プログラム・要旨集(Web) 2021)
  • 抗SARS-CoV-2スーパー中和抗体
    (日本人類遺伝学会大会プログラム・抄録集 2021)
  • Development of human neutralizing monoclonal antibodies for prevention of SARS-CoV-2 infections
    (日本ウイルス学会学術集会プログラム・予稿集(Web) 2021)
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Education (4)：
  • - 1984 Toyama Medical and Pharmaceutical University
  • - 1984 Toyama Medical and Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
  • - 1979 University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences
  • - 1979 University of Toyama Faculty of Pharmaceutical Science
Professional career (1)：
  • Doctor of Pharmaceutical Sciences (Toyama Medical and Pharmaceutical University)
Awards (2)：
  • 1990 - 富山賞
  • 1990 - Toyama Award
Association Membership(s) (5)：
Society for Senescence-Accelerated Mouse (SAM) Research ,  日本薬学会 ,  日本人類遺伝学会 ,  癌学会 ,  日本分子生物学会
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