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J-GLOBAL ID：200901080359350840 Update date: Mar. 22, 2025

Asai Masato

アサイマサト | Asai Masato

Affiliation and department：
Job title： Chief

Research field (2)： Laboratory animal science , Metabolism and endocrinology

Research keywords (3)： Brain Neuroscience , Endocrinology , endocrinology

Research theme for competitive and other funds (10)：

2023 - 2026 Research on the search for mediators of epileptic wave propagation using a mouse model of hereditary epilepsy
2022 - 2025 新規単遺伝子てんかんモデルを用いたてんかん病態の解明
2019 - 2022 Epilepsy in Girdin/ccdc88a knockout mice
2017 - 2022 Investigation of pathogenesis of mesial temporal epilepsy using monogenic mouse model
2017 - 2021 MTLE and inefficient neuronal secreiton

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Papers (95)：

Motoki Tanaka, Masahiro Sokabe, Keiko Nakanishi, Masato Asai. Effects of nestorone, a progesterone receptor agonist, on neonatal hypoxic-ischemic brain injury and reproductive functions in male and female rats. Neuropharmacology. 2025. 271. 110411-110411
Machiko Iida, Motoki Tanaka, Tsuyoshi Takagi, Tohru Matsuki, Kimihiro Kimura, Kazuki Shibata, Yohei Kobayashi, Yuka Mizutani, Haruki Kuwamura, Keitaro Yamada, et al. Girdin deficiency causes developmental and epileptic encephalopathy with hippocampal sclerosis and interneuronopathy. Epilepsia. 2024. 66. 2. 699-617
Motoki Tanaka, Masahiro Sokabe, Masato Asai. Progesterone Receptor Agonist, Nestorone, Exerts Long-Term Neuroprotective Effects Against Permanent Focal Cerebral Ischemia in Adult and Aged Male Rats. Translational Stroke Research. 2024
Hidenori Tabata, Daisuke Mori, Tohru Matsuki, Kaichi Yoshizaki, Masato Asai, Atsuo Nakayama, Norio Ozaki, Koh-ichi Nagata. Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome. Biomolecules. 2023. 13. 5. 763-763
Keiko Nakanishi, Kyohei Higashi, Toshihiko Toida, Masato Asai. Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats. PLOS ONE. 2022. 17. 1. e0262854-e0262854

MISC (9)：

ASAI Masato. FACEBOOK Journal of Histochemistry & Cytochemistry 3D-image of tuft cells. 2018
浅井真人. 免疫生物研究所(IBL) pY1798抗体紹介画像提供. 2018
ASAI Masato. FACEBOOK Journal of Histochemistry & Cytochemistry Portal site image. 2017
Yoshiki Murakumo, Naoki Watanabe, Shinji Mii, Masato Asai, Naoya Asai, Kaoru Niimi, Takuya Kato, Atsushi Enomoto, Masahide Takahashi. DNA repair protein Rev7 is required for primordial germ cell maintenance in the mouse. CANCER RESEARCH. 2014. 74. 19
ASAI Masato. Loss of function of MRAP2 is associated with obesity. 2013

Patents (6)：

KNOCKOUT MOUSE, METHOD FOR SCREENING SUBSTANCE FOR SUPPRESSING MESIAL TEMPORAL LOBE EPILEPSY, AND METHOD FOR SELECTING TECHNIQUE OR SUPPRESSING MESIAL TEMPORAL LOBE EPILEPSY
Knock-out mouse, method of screening material suppressing mesial temporal lobe epilepsy, and method of selecting technique for suppressing mesial temporal lobe epilepsy
MRAP2 Knockout
A method for accelerating a weight gain of a non-human mammal, wherein a Mrap2 gene in the mammal is modified to obtain a Mrap2 knockout mammal, wherein the mammal does not express a detectable level of functional Mrap2.
ノックアウトマウス、内側側頭葉てんかんを抑制する物質のスクリーニング方法、及び内側側頭葉てんかんを抑制する手法の選択方法

Books (3)：

Lectures and oral presentations (27)：

Preliminary Investigation of Whole Brain Energy Metabolism in the DEE/MTLE Animal Model
(The National Institute for Physiological Sciences The 54th International Symposium 2024)
Preliminary Investigation of Whole Brain Energy Metabolism in the DEE/MTLE Animal Model
(NEURO2024 2024)
Mouse model of hereditary intractable epilepsy
(2023)
Animals for Antiepileptic Drug Testing
(2023)
Developmental / Epileptic Encephalopathy with Spike Wave Activation on Sleep (DEE-SWAS)-like phenotypes in a mouse model of hereditary intractable epilepsy
(Neuro2023 2023)

Education (4)：

Professional career (2)：

Work history (10)：

2019/03 - 現在 Aichi Developmental Disability Center Department of Disease Model Chief
2017/04 - 2019/02 Aichi Human Service Center Institute for Developmental Research Chief
2016/04 - 2017/03 Nagoya University Graduate School of Medicine Tumor Pathology Adjunct Associate Professor
2009/08 - 2016/03 Nagoya University Graduate School of Medicine Tumor Pathology Adjunct Lecturer
2009/01 - 2009/07 Research Institute of Environment Medicine Nagoya University Visiting Fellow

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Awards (3)：

2026/03 - The Japan Epilepsy Research Foundation (JERF) 2025 Research Award (Basic) Identification of Girdin, a common epilepsy-causing gene in humans and mice
2016/12 - 八木基金海外研究交流助成海外研究交流助成
2003 - 神経内分泌学会若手研究奨励賞受賞 Nuclear orphan receptor Nurr1は、thyrotrophにおけるTRH依存性αサブユニット遺伝子発現を仲介している

Association Membership(s) (5)：

THE JAPAN NEUROSCIENCE SOCIETY , American Epilepsy Society , Japan Neuroendocrine Society , 日本内分泌学会 , 日本内科学会

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