Yasui Hiroyuki

ヤスイヒロユキ | Yasui Hiroyuki

Affiliation and department：
Homepage URL (1)： http://labo.kyoto-phu.ac.jp/taisya/

Research field (4)： Clinical pharmacy , Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (8)：応用薬理学 , 医療系薬学 , 創薬化学 , 物理系薬学 , 医薬分子機能学 , Pharmacentical Environmental Science , Physical Pharmacology , Molecular Pharmacology

Research theme for competitive and other funds (28)：

2023 - 2026 Comprehensive Examination of Novel Risk Factors for Development of Lifestyle-related Diseases by Metallomics Analysis by Molecular Weight
2020 - 2023 Pathological analysys and new therapeutic development for inflammatory bowel diseaseon on the molecular basis of fluctuant activity of zinc-requiring enzyme
2017 - 2019 Development and application of novel chemical compounds to materialize the cancer theranostics
2014 - 2017 Development of orally active zinc complexes enhancing and controlling the function of endogenous insulin as a novel anti-diabetic candidate
2012 - 2017 バイオメタルと生体反応の連関解明に基づいた疾患治療ファルマコメタロミクスの確立

2011 - 2014 Development of anti-diabetic zinc medicine protecting the pancreatic B cells through the GPR39-stimulating Pdx-1 expression

2012 - 2013 新規ビタミンC誘導体-亜鉛錯体による膵β細胞保護治療薬の開発

2011 - 2013 Studies on regulation of neutrophilic airway inflammation in severe asthma and chronic obstructive pulmonary disease (COPD)

2012 - 2012 Potential of cisplatin derivatives as antifibrotic drugs

2010 - 2011 A novel drug carrier based on the collagen-like triple-helical peptide

2009 - 2010 天然型トロポロン-亜鉛錯体の開発と肥満・糖尿病治療への応用

2007 - 2010 生活習慣病を予防および改善する亜鉛錯体の開発研究

2008 - 2010 Development of inorganic zinc-containing medicines with anti-obesity action

2008 - 2009 Developmental challenges for drug delivery system targetin g to neurodegenerative area

2006 - 2007 Development of anti-diabetic agents based on investigating the mechanism of the onset of type 2 diabetes due to protein glycosilation

2004 - 2006 Development of Metal Complexes with Antidialetic Effect

2004 - 2005 Study on development of anti-septic zinc(II) complex with immune-enhancing activity

2003 - 2005 Analyses of induction mechanisms underlying nasal blockage and nasal hyperresponsiveness using an experimental model of allergic rhinitis

2003 - 2004 高活性インスリン様亜鉛錯体の構築と動的機構の解明

2003 - 2004 高活性長期持続性経口抗糖尿病治療薬としてのバナジウムおよび亜鉛錯体の開発研究

2002 - 2003 生体膜透過性ペプチド誘導体を配位子とするインスリン様バナジウム錯体の設計と評価

2000 - 2001 光照射下の皮膚で生成される活性酸素・フリーラジカル種のインビボ画像化検出法の開発

1999 - 2001 Research and Development of Protective Compounds against UV Iight-induced Skin Damage on the Basis of anti-ROS properties

1999 - 2000 生体NOのバナジウムによる制御を目指したインスリン様バナジウム錯体の開発研究

1997 - 1998 肝臓癌を発症させる肝線維症や肝硬変の予防および治療に関する薬物動態学的研究

1996 - 1997 Studies on orally active antidiabetic vanadium complexes with low toxicity and long-term action

1996 - 1996 抗エイズ薬のリンパ組織指向化に関する薬物動態学的研究

1993 - 1995 Enhanced Efficacy of Immunosuppressant by Modification at Molecular Level

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Papers (283)：

Nagisa Ishida, Yuuki Nishida, Shohei Hamada, Hiroyuki Yasui, Takumi Furuta, Yusuke Kobayashi. Brønsted Acid-Stibine Oxide Complexes as Organocatalysts for the Activation of Alkenes. Asian Journal of Organic Chemistry. 2024
Yuto Kondo, Hiroyuki Kimura, Mamiko Tanaka, Yasunao Hattori, Hidekazu Kawashima, Kazuhiro Takahashi, Hiroyuki Yasui. Mechanistic Insights into the Effect of Sodium Iodide on Copper-Mediated Iododeboronation. Chemistry - A European Journal. 2024
Yukina Nishito, Yoshiki Kamimura, Shino Nagamatsu, Nao Yamamoto, Hiroyuki Yasui, Taiho Kambe. Zinc and manganese homeostasis closely interact in mammalian cells. The FASEB Journal. 2024. 38. 7
Hiroyuki Yasui. MRI-Based Risk Factors for Adverse Maternal Outcomes in Prophylactic Aortic Balloon Occlusion for Placenta Accreta Spectrum and Placenta Previa. Diagnostics. 2024
Yuto Kondo, Hiroyuki Kimura, Ryota Chisaka, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui. One-pot two-step radioiodination based on copper-mediated iododeboronation and azide-alkyne cycloaddition reaction. Chemical Communications. 2024. 60. 6. 714-717

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MISC (229)：

面川真里奈, 木村寛之, 木村寛之, 初川雄一, 河嶋秀和, 塚田和明, 屋木裕亮, 内藤行喜, 安井裕之. Synthesis and biological evaluation of a novel sugar-conjugated platinum complex having a tumor-targeting effect and ¹⁹¹Pt labeled complex. 日本薬学会年会要旨集(Web). 2024. 144th
安井友佳子, 山本圭城, 石坂敏彦, 安井裕之. ボリコナゾールの血中トラフ濃度の個体間変動に影響する因子の探索と遺伝子多型情報を用いない血中濃度予測式の提案. TDM研究. 2023. 40. 2. 197-197
近藤悠斗, 木村寛之, 河嶋秀和, 服部恭尚, 安井裕之. Copper-mediated one-pot radioiodination on a resin. 日本薬学会年会要旨集(Web). 2023. 143rd
面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之. Evaluation of biodistribution of a novel sugar-conjugated platinum complex and its complex labeled with ¹⁹¹Pt in mice. 日本薬学会年会要旨集(Web). 2023. 143rd
古川武典, 木村寛之, 志賀智華, 吉村茜音, 屋木祐亮, 屋木祐亮, 河嶋秀和, 安井裕之. Research on development of [¹²⁵I]EFT-7 as an imaging tracer targeting Erythropoietin-producing hepatocellular receptor A2. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (12)：

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Books (24)：

酸化ストレスの医学(改訂第3版)
診断と治療社 2024
コンパス分析化学[電子版付](改訂第3版増補)
南江堂 2024 ISBN:9784524404551
化学物質の分析
東京化学同人 2022 ISBN:9784807917280
コンパス分析化学(改訂第3版)
南江堂 2021 ISBN:9784524403868
臨床分析学のサブノート
京都廣川書店 2018 ISBN:9784909197337

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Lectures and oral presentations (149)：

造血幹細胞移植患者におけるポサコナゾール血中濃度に影響を与える因子の解析~薬剤肝代謝率と遺伝子多型の影響~
(第33回日本医療薬学会年会 2023)
硫黄化したヒノキチオール/亜鉛錯体の合成とマウス皮膚移行性の検討
(第73回日本薬学会関西支部総会・大会 2023)
『亜鉛は未来を拓く「がん・生殖・COVID-19」』COVID-19重症化と低亜鉛血症との連関から私たちが学ぶべきこと-これからの健康格差縮小とゼロ次予防に向けて-
(第34回日本微量元素学会学術集会 2023)
65Cu/63Cu の安定同位体比分析を用いた病態診断法の開発-潰瘍性大腸炎を取り上げて-
(第35回バイオメディカル分析科学シンポジウム 2023)
『分析科学で代謝が分かる』亜鉛輸送体の発現制御を基軸とした亜鉛代謝維持機構の理解
(第35回バイオメディカル分析科学シンポジウム 2023)

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Education (3)：

1991 - 1995 Kyoto University
1989 - 1991 Kyoto University
1985 - 1989 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (2)：

Master of Science.
Ph. D

Work history (4)：

2007/10 - 現在 Kyoto Pharmaceutical University Pharmaceutical Sciences
2007/04 - 2007/09 Kyoto Pharmaceutical University Pharmaceutical Sciences
2004/04 - 2007/03 Kyoto Pharmaceutical University Pharmaceutical Sciences
1995/04 - 2004/03 Kyoto Pharmaceutical University Pharmaceutical Sciences

Awards (1)：

2000 - 日本薬学会近畿支部奨励賞

Association Membership(s) (11)：

カロテノイド研究会 , JAPAN SOCIETY OF COORDINATION CHEMISTRY , The Japanese Peptide Society , 日本TDM学会 , SOCIETY FOR FREE RADICAL RESEARCH JAPAN , THE SOCIETY OF ELECTRON SPIN SCIENCE AND TECHNOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , JAPAN SOCIETY FOR BIOMEDICAL RESEARCH ON TRACE ELEMENTS , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本分析化学会

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