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J-GLOBAL ID：201801006061159734 Update date: Mar. 17, 2025

Mizuguchi Kenji

ミズグチケンジ | Mizuguchi Kenji

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Affiliation and department：
Job title： Professor
Homepage URL (1)： https://mizuguchilab.org

Research field (2)： Systems genomics , Biological, health, and medical informatics

Research keywords (15)： bioinformatics , computational biology , drug discovery , network biology , disease biology , protein structure , protein interaction , data integration , database , artificial intelligence , machine learning , pharmacokinetics , gut microbiota , omics , drug design

Research theme for competitive and other funds (22)：

2022 - 2025 静的局所環境の学習によるタンパク質動的構造情報の抽出
2020 - 2023 International research project on nucleic acid aptamers and their exosome-based application to therapeutics for synucleinopathy
2017 - 2020 Improved identification of drug targets by data warehousing and simulations of signal transduction pathways
2017 - 2019 Drug discovery in breast cancer utilizing reactivation of tumor suppressors
2016 - 2019 Clarification of novel pathophysiological roles of BIG3 in breast cancer cells

2016 - 2019 Examination of regulatory network profiles for gene expression of intestinal epithelial barrier dysfunction in aging

2015 - 2019 多階層データの統合モデリングによる薬物動態予測システムの構築

2017 - 2018 革新的技術に裏打ちされた有効かつ安全な次世代アジュバント開発

2016 - 2018 創薬を指向したタンパク質の結合部位予測アルゴリズムの開発

2016 - 2018 食-腸-医をつなぐ生活習慣病の新規メカニズムの解明と腸内細菌叢やその代謝物に着目した病態制御法の開発

2015 - 2018 生活習慣病やアレルギー疾患の新しい予防法確立に資する健康な日本人の腸管免疫と腸内細菌データベースの構築に関する疫学研究

2012 - 2017 アジュバント安全性評価データベースの構築研究

2013 - 2016 Drug development and biological function study of novel estrogen receptor activity modulator BIG3 protein

2013 - 2016 Development of a target discovery platform by integrating data warehousing and protein function prediction

2013 - 2016 創薬支援のためのバイオリソースデータベースのネットワーク整備と政策・倫理課題に関する研究

2013 - 2014 化粧品等のQSAR/in silico/インフォマテクス技術等の安全性評価応用に関する調査研究

2011 - 2014 ヒトES/iPS細胞の実用化における幹細胞バンクの基盤整備についての研究

2011 - 2013 疾患関連タンパク質における機能決定アミノ酸残基の予測

2010 - 2013 疾患研究のための生物資源の所在情報データベース等の構築と維持と関連する政策・倫理課題の研究

2007 - 2012 国際バリューチェインによる創薬ターゲットタンパク質の阻害剤開発プログラム

2007 - 2011 タンパク質のネットワーク分子機能予測による創薬ターゲット同定手法の開発

2007 - 2010 ダイナミクスを考慮した膜蛋白質の構造モデリング法の開発

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Papers (192)：

Bayu Ardiansah, Ahmad Farhan, Novita Sari Nurhasanah, Mochammad Arfin Fardiansyah Nasution, Noordini M. Salleh, Kenji Mizuguchi, Antonius Herry Cahyana, Lina Mardiana. Dual antioxidant and cytotoxic activities of novel 1,2,3-triazole-decorated unsymmetrical monocarbonyl curcumin analogs. Case Studies in Chemical and Environmental Engineering. 2025. 11. 101031-101031
Qiuyi Wang, Zi Wang, Kenji Mizuguchi, Toshifumi Takao. Biological age prediction using a DNN model based on pathways of steroidogenesis. Science Advances. 2025. 11. 11
Miki Doi, Rikako Inoue, Koji Hosomi, Jonguk Park, Hitomi Yumioka, A. Yasmin Syauki, Suzumi Kageyama, Haruka Sakaue, Kozo Tanabe, Kenji Mizuguchi, et al. Effects of Malted Rice Amazake Consumption on Nutritional Status and Gut Microbiome in Older Patients and Residents of an Integrated Facility for Medical and Long-Term Care. Journal of Nutrition in Gerontology and Geriatrics. 2025. 1-23
Rikako Inoue, Koji Hosomi, Jonguk Park, Haruka Sakaue, Hitomi Yumioka, Hiroko Kamitani, Yoshiharu Kinugasa, Kaori Harano, A. Yasmin Syauki, Miki Doi, et al. Clinical Phenotypes Associated with the Gut Microbiome in Older Japanese People with Care Needs in a Nursing Home. Nutrients. 2024. 16. 22. 3839-3839
Satoko Maruyama, Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Haruka Murakami, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Tadao Ooka, et al. High barley intake in non-obese individuals is associated with high natto consumption and abundance of butyrate-producing bacteria in the gut: a cross-sectional study. Frontiers in Nutrition. 2024. 11

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MISC (59)：

Lokesh P. Tripathi, Rodolfo S. Allendes Osorio, Yoichi Murakami, Yi-An Chen, Kenji Mizuguchi. Network-Based Analysis for Biological Knowledge Discovery. Reference Module in Life Sciences. 2024
Hiroshi Komura, Reiko Watanabe, Kenji Mizuguchi. The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery. Pharmaceutics. 2023. 15. 11. 2619-2619
MARTIN, 渡邉怜子, 水口賢司. ナノ粒子をより安全に設計するための新手法 --ナノ粒子の安全性に革命を: AI が拓く未来. 化学. 2023. 78. 11. 27-30
Yoichi Murakami, Kenji Mizuguchi. Recent developments of sequence-based prediction of protein-protein interactions. Biophysical reviews. 2022. 1-19
Masataka Kuroda, Reiko Watanabe, Tsuyoshi Esaki, Hitoshi Kawashima, Rikiya Ohashi, Tomohiro Sato, Teruki Honma, Hiroshi Komura, Kenji Mizuguchi. Utilizing public and private sector data to build better machine learning models for the prediction of pharmacokinetic parameters. Drug discovery today. 2022. 103339-103339

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Patents (3)：

エピトープ均質化抗体パネル、ならびにその作製方法および利用
遺伝子絞り込み装置、遺伝子絞り込み方法、及びコンピュータプログラム
Device and method for selecting genes and proteins

Books (18)：

健康と疾患を制御する精密栄養学 : 「何を、いつ、どう食べるか?」に、食品機能の解析と個人差を生む分子メカニズムの解明から迫る
羊土社 2023 ISBN:9784758104111
ケモインフォマティクスにおけるデータ収集の最適化と解析手法
技術情報協会 2023 ISBN:9784861049446
革新的AI創薬 : 医療ビッグデータ、人工知能がもたらす創薬研究の未来像
エヌ・ティー・エス 2022 ISBN:9784860437886
創薬研究のための相互作用解析パーフェクト : 低中分子・抗体創薬におけるスクリーニング戦略と実例、in silico解析、一歩進んだ分析技術まで
羊土社 2021 ISBN:9784758122566
Protein Interactions: Computational Methods, Analysis and Applications
World Scientific 2020

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Lectures and oral presentations (133)：

DruMAP: a drug metabolism and pharmacokinetics analysis platform
(Chem-Bio Informatics Society (CBI) Annual Meeting 2024 2024)
Data integration as a basis for multi-faceted modeling: towards AI-driven drug discovery
(Chem-Bio Informatics Society (CBI) Annual Meeting 2024 2024)
Artificial Intelligence-driven drug discovery and data integration
(JASIS 2024 2024)
ナノ粒子の安全性予測
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)
Data integration and curation as a basis for AI-based drug discovery
(11th OU Bioinformatics Center Seminar 2024)

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Education (3)：

1992 - 1995 Kyoto University Department of Chemistry
1990 - 1992 Kyoto University Department of Chemistry
1986 - 1990 Kyoto University Faculty of Science

Professional career (1)：

PhD (Kyoto University)

Work history (9)：

2019/10 - 現在 Institute for Protein Research, Osaka University Professor
2019/07 - 2024/03 National Institutes of Biomedical Innovation, Health and Nutrition Artificial Intelligence Center for Health and Biomedical Research Director
2013/05 - 2024/03 National Institutes of Biomedical Innovation, Health and Nutrition Laboratory of In silico design Research Group Head
2006/10 - 2021/08 National Institutes of Biomedical Innovation, Health and Nutrition Laboratory of Bioinformatics Research Group Head
2004/10 - 2006/09 University of Cambridge Department of Applied Mathematics and Theoretical Physics Lecturer

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Committee career (16)：

2021/04 - 現在日本バイオインフォマティクス学会幹事、第11回生命医薬情報学連合大会(IIBMP2022)大会長
2020/04 - 現在日本学術振興会 R022 量子構造生物学委員会学会委員
2019/04 - 現在日本メディカルAI学会評議員
2017 - 現在ライフインテリジェンスコンソーシアム(LINC) 副代表
2014/04 - 現在 Chem-Bio Informatics Society Board member

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Awards (3)：

2020/02 - Japan Open Innovation Prize(JOIP)
2000/06 - Wellcome Trust Research Career Development Fellowship
1996/10 - HFSP (Human Frontier Science Program) Long-Term fellowship

Association Membership(s) (4)：

情報計算化学生物学会(CBI学会) , 日本メディカルAI学会 , 日本バイオインフォマティクス学会 , 日本生物物理学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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