Rchr
J-GLOBAL ID:201801021323593642   Update date: Sep. 01, 2020

Serizawa Masakuni

セリザワマサクニ | Serizawa Masakuni
Affiliation and department:
Homepage URL  (1): https://www.scchr.jp/researchinstitute/dept_intro/new_medicine_lab.html
Research field  (3): Tumor biology ,  Bacteriology ,  Genomics
Research keywords  (15): Liquid biopsy ,  EGFR ,  抗がん剤耐性 ,  胃癌 ,  頭頸部癌 ,  肺癌 ,  トランスレーショナルリサーチ ,  p53 ,  核内レセプター ,  シグナル伝達 ,  Liquid biopsy ,  分子標的治療薬 ,  腫瘍生物学 ,  がん代謝標的療法 ,  がんゲノム医療
Research theme for competitive and other funds  (6):
  • 2019 - 2022 がんゲノム解析で蓄積する機能未知遺伝子変異の臨床活用にむけた変異機能推定法の構築
  • 2015 - 2018 肺癌治療におけるEGFR-TKI耐性克服にむけた代謝経路を標的とする治療法の開発
  • 2013 - 2015 非小細胞肺癌におけるEGFR-TKI治療耐性化後の転移に関する新規分子機序の解明
  • 2012 - 2015 胸部悪性腫瘍における分子生物学的診断の試みと新規バイオマーカーの探索研究
  • 2011 - 2013 GLUT1を新規治療効果予測マーカーに用いた肺がんの個別化医療の実現にむけた研究
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Papers (54):
  • Ono A, Isaka M, Serizawa M, Omae K, Kojima H, Nakashima K, Omori S, Wakuda K, Kenmotsu H, Naito T, et al. Genetic alterations of driver genes as independent prognostic factors for disease-free survival in patients with resected non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). 2019. 128. 152-157
  • Keiichi Hatakeyama, Keiichi Ohshima, Takeshi Nagashima, Shumpei Ohnami, Sumiko Ohnami, Masakuni Serizawa, Yuji Shimoda, Koji Maruyama, Yasuto Akiyama, Kenichi Urakami, et al. Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. Scientific Reports. 2018. 8. 1. 8700
  • Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa, Yasuhiro Koh. PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue. BMC cancer. 2018. 18. 1. 826-826
  • Keiichi Hatakeyama, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Masakuni Serizawa, Sumiko Ohnami, Yuji Shimoda, Shumpei Ohnami, Koji Maruyama, Akane Naruoka, et al. Tumor mutational burden analysis of 2,000 Japanese cancer genomes using whole exome and targeted gene panel sequencing. Biomedical Research (Japan). 2018. 39. 3. 159-167
  • Mitsuhiro Isaka, Masakuni Serizawa, Hirotsugu Kenmotsu, Yasuhiro Koh, Shoji Takahashi, Tomohiro Maniwa, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, et al. Comparison of Clinically Relevant Mutation Profiles Between Preoperative Biopsy and Corresponding Surgically Resected Specimens in Japanese Patients With Non-Small-cell Lung Cancer by Amplicon-based Massively Parallel Sequencing. CLINICAL LUNG CANCER. 2017. 18. 5. 519-+
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MISC (1):
  • 芹澤昌邦, 洪泰浩. バイオバンクと個別化医療. PROGRESS IN MEDICINE. 2011. 31. 11. 2575-2580
Professional career (1):
  • 博士(工学) (信州大学)
Awards (1):
  • 2011 - がん研究振興財団 平成23年度海外派遣研究助成金
Association Membership(s) (4):
American Association for Cancer Research ,  THE JAPAN LUNG CANCER SOCIETY ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  THE JAPANESE CANCER ASSOCIATION
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