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J-GLOBAL ID：202002288761810068   Reference number：20A1433675

Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity

肥満におけるTLR4シグナル伝達におけるGM3ガングリオシド分子種の恒常性および病原性の役割【JST・京大機械翻訳】

Author (34)： Kanoh Hirotaka (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Nitta Takahiro (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Go Shinji (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Inamori Kei-ichiro (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Veillon Lucas (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Nihei Wataru (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Fujii Mayu (Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan) ,  Kabayama Kazuya (Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan) ,  Shimoyama Atsushi (Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan) ,  Fukase Koichi (Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan) ,  Ohto Umeharu (Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan) ,  Shimizu Toshiyuki (Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan) ,  Watanabe Taku (Medical and Pharmaceutical Information Science, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Shindo Hiroki (Medical and Pharmaceutical Information Science, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Aoki Sorama (Medical and Pharmaceutical Information Science, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Sato Kenichi (Medical and Pharmaceutical Information Science, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Nagasaki Mika (Department of Cardiovascular Medicine and Computational Diagnostic Radiology & Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Yatomi Yutaka (Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Komura Naoko (Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, Gifu, Japan) ,  Ando Hiromune (Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, Gifu, Japan) ,  Ishida Hideharu (Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, Gifu, Japan) ,  Ishida Hideharu (Department of Applied Bio-organic Chemistry, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan) ,  Kiso Makoto (Organization for Research and Community Development, Gifu University, Gifu, Japan) ,  Natori Yoshihiro (Division of Organic and Pharmaceutical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Yoshimura Yuichi (Division of Organic and Pharmaceutical Chemistry, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Zonca Asia (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Cattaneo Anna (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Letizia Marilena (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Ciampa Maria (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Mauri Laura (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Prinetti Alessandro (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Sonnino Sandro (Department of Medical Biotechnology and Translational Medicine, University of Milan, Milano, Italy) ,  Suzuki Akemi (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Inokuchi Jin-ichi (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan)
Material： EMBO Journal  (EMBO J)
Volume： 39  Issue： 12  Page： e101732  Publication year： 2020 
JST Material Number： A0911B  ISSN： 0261-4189  CODEN： EMJODG  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Innate immune signaling via TL...

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Thesaurus term： interaction ,  hydrophobic ,  fatty acid ,  inflammation ,  serum concentration ,  *obesity ,  long chain ,  monocyte ,  *cellular signal transduction ,  pathogenesis
Semi thesaurus term： リガンド ,  アゴニスト ,  アンタゴニスト ,  MD2 ,  *Toll様受容体4 , 【Automatic Indexing@JST】

Author keywords (5)： chronic inflammation ,  ganglioside GM3 ,  inflammation amplification loop ,  obesity ,  TLR4

JST classification (3)： Cell physiology in general  (EF02010S) ,  Physiology and pathogenicity of virus infection  (EG04042Y) ,  Function of cell components  (EF03060C)

Terms in the title (8)： 肥満 ,  TLR4 ,  シグナル伝達 ,  GM3ガングリオシド ,  分子種 ,  恒常性 ,  病原性 ,  役割