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J-GLOBAL ID：201802285458249793   整理番号：18A1712970

自閉症スペクトラム障害と統合失調症におけるコピー数変動の比較分析は,重複と生物学的洞察を明らかにする【JST・京大機械翻訳】

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

著者 (93件)： Kushima Itaru (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Kushima Itaru (Institute for Advanced Research, Nagoya University, Nagoya, Aichi 464-8601, Japan) ,  Aleksic Branko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Nakatochi Masahiro (Division of Data Science, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan) ,  Shimamura Teppei (Division of Systems Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Okada Takashi (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Uno Yota (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Uno Yota (Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA) ,  Morikawa Mako (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Ishizuka Kanako (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Shiino Tomoko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Shiino Tomoko (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan) ,  Kimura Hiroki (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Arioka Yuko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Arioka Yuko (Institute for Advanced Research, Nagoya University, Nagoya, Aichi 464-8601, Japan) ,  Arioka Yuko (Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan) ,  Yoshimi Akira (Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, Nagoya, Aichi 468-8503, Japan) ,  Takasaki Yuto (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Yu Yanjie (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Nakamura Yukako (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Yamamoto Maeri (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Iidaka Tetsuya (Department of Physical and Occupational Therapy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673, Japan) ,  Iritani Shuji (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Inada Toshiya (Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Ogawa Nanayo (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Shishido Emiko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Torii Youta (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Torii Youta (Center for Postgraduate Clinical Training and Career Development, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan) ,  Kawano Naoko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Kawano Naoko (Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi 464-8601, Japan) ,  Omura Yutaka (Aichi Psychiatric Medical Center, Nagoya, Aichi 464-0031, Japan) ,  Yoshikawa Toru (Department of Child Psychiatry, Aichi Prefectural Colony Central Hospital, Kasugai, Aichi 480-0392, Japan) ,  Uchiyama Tokio (Department of Clinical Psychology, Taisho University, Tokyo 170-8470, Japan) ,  Yamamoto Toshimichi (Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Ikeda Masashi (Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan) ,  Hashimoto Ryota (Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hashimoto Ryota (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan) ,  Hashimoto Ryota (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan) ,  Yamamori Hidenaga (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan) ,  Yasuda Yuka (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan) ,  Someya Toshiyuki (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Watanabe Yuichiro (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Egawa Jun (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Nunokawa Ayako (Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan) ,  Itokawa Masanari (Center for Medical Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Arai Makoto (Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Miyashita Mitsuhiro (Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Kobori Akiko (Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan) ,  Suzuki Michio (Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930-0194, Japan) ,  Takahashi Tsutomu (Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930-0194, Japan) ,  Usami Masahide (Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan) ,  Kodaira Masaki (Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan) ,  Watanabe Kyota (Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan) ,  Sasaki Tsukasa (Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo 113-0033, Japan) ,  Kuwabara Hitoshi (Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan) ,  Tochigi Mamoru (Department of Neuropsychiatry, Teikyo University School of Medicine, Tokyo 173-8605, Japan) ,  Nishimura Fumichika (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Yamasue Hidenori (Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan) ,  Eriguchi Yosuke (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Benner Seico (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kojima Masaki (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Yassin Walid (Department of Child Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Munesue Toshio (Research Center for Child Mental Development, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan) ,  Yokoyama Shigeru (Research Center for Child Mental Development, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan) ,  Kimura Ryo (Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan) ,  Funabiki Yasuko (Department of Cognitive and Behavioral Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan) ,  Kosaka Hirotaka (Research Center for Child Mental Development University of Fukui, Eiheiji, Fukui 910-1193, Japan) ,  Kosaka Hirotaka (Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui 910-1193, Japan) ,  Ishitobi Makoto (Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui 910-1193, Japan) ,  Ishitobi Makoto (Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan) ,  Ohmori Tetsuro (Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan) ,  Numata Shusuke (Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan) ,  Yoshikawa Takeo (Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Toyota Tomoko (Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Yamakawa Kazuhiro (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Suzuki Toshimitsu (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Inoue Yushi (National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, Shizuoka 420-8688, Japan) ,  Nakaoka Kentaro (Aichi Psychiatric Medical Center, Nagoya, Aichi 464-0031, Japan) ,  Goto Yu-ichi (Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan) ,  Inagaki Masumi (Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan) ,  Hashimoto Naoki (Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Sapporo 060-8638, Japan) ,  Kusumi Ichiro (Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Sapporo 060-8638, Japan) ,  Son Shuraku (Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Murai Toshiya (Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Ikegame Tempei (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Okada Naohiro (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kasai Kiyoto (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kasai Kiyoto (The International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study (UTIAS), Tokyo 113-0033, Japan) ,  Kunimoto Shohko (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Mori Daisuke (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan) ,  Mori Daisuke (Brain and Mind Research Center, Nagoya University, Nagoya, Aichi 466-8550, Japan) ,  Iwata Nakao (Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan) ,  Ozaki Norio (Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan)
資料名： Cell Reports  (Cell Reports)
巻： 24  号： 11  ページ： 2838-2856  発行年： 2018年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 白人集団における説得力のある証拠は自閉症スペクトラム障害(ASD)と統合失調症(SCZ)におけるコピー数変化(CNVs)の役割を示唆する。日本人集団における1,108人のASD症例,2,458人のSCZ症例,および2,095人の対照を分析し,両疾患における稀な外来性CNVsの増加した負担を確認した。両疾患に共通する29の遺伝子座を含む臨床的に有意な(または病原性)CNVsは,ASDおよびSCZ症例の約8%で見出され,対照より有意に高かった。表現型分析は,臨床的に有意なCNVsと知的障害の間の関連を明らかにした。遺伝子セット分析は,酸化ストレス応答,脂質代謝/修飾およびゲノム完全性を含む両疾患における生物学的経路の有意な重複を示した。最後に,生物情報学分析に基づいて,8つの良く知られたASD-SCZ関連CNV遺伝子座(例えば,22q11.2,3q29)における複数の疾患関連遺伝子を同定した。本知見はASDとSCZの病因的重複を示唆し,これらの疾患に生物学的洞察を提供する。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *コピー数 ,  完全性 ,  遺伝子 ,  ゲノム ,  表現型 ,  脂質代謝 ,  酸化ストレス ,  *統合失調症 ,  知能障害 ,  遺伝 ,  病因
準シソーラス用語： バイオインフォマティクス ,  日本人 ,  白人 ,  *自閉症スペクトラム障害 , 【Automatic Indexing@JST】

著者キーワード (10件)： 自閉症スペクトラム障害 ,  分裂病 ,  コピー数変動 ,  アレイ比較ゲノムハイブリダイゼーション ,  遺伝的重複 ,  日本人集団 ,  酸化ストレス応答 ,  ゲノムの完全性 ,  脂質代謝 ,  遺伝子オントロジー

分類 (2件)： 遺伝的変異  (EC01030Y) ,  分子遺伝学一般  (EC02010J)

タイトルに関連する用語 (6件)： 自閉症スペクトラム障害 ,  統合失調症 ,  コピー数 ,  比較分析 ,  生物学 ,  洞察