Ochi Yosuke

Research field (2)： Hematology and oncology , Pharmaceuticals - chemistry and drug development

Research keywords (5)：血小板 , RNA , siRNA , プロドラッグ , 核酸化学

Research theme for competitive and other funds (1)：

2018 - 2020 炎症性副作用を軽減したプロドラッグ型siRNAの開発

Papers (9)：

Junsuke Hayashi, Yosuke Ochi, Kota Senpuku, Shun-Ichi Wada, Fumito Wada, Mariko Harada-Shiba, Hidehito Urata. Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency. Bioorganic & medicinal chemistry. 2024. 104. 117693-117693
Hisako Mitsuhashi, Yosuke Ochi, Akihiro Fuchizaki, Ryuunosuke Ooba, Tomoya Hayashi, Yoshinori Horie, Tomoko Kawamura, Mitsunobu Tanaka, Yoshihiro Takihara, Kazushige Shimogaki, et al. Automated preparation of washed platelet concentrates through spinning-membrane filtration. Transfusion. 2022. 62. 11. 2262-2270
Hayashi J, Ochi Y, Morita Y, Soubou K, Ohtomo Y, Nishigaki M, Tochiyama Y, Nakagawa O, Wada SI, Urata H. Syntheses of prodrug-type 2'-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2'-hydroxy oligonucleotides under reducing condition. Bioorganic & medicinal chemistry. 2018
Junsuke Hayashi, Misa Nishigaki, Yosuke Ochi, Shun-Ichi Wada, Fumito Wada, Osamu Nakagawa, Satoshi Obika, Mariko Harada-Shiba, Hidehito Urata. Effective gene silencing activity of prodrug-type 2'-O-methyldithiomethyl siRNA compared with non-prodrug-type 2'-O-methyl siRNA. Bioorganic & medicinal chemistry letters. 2018. 28. 12. 2171-2174
Junsuke Hayashi, Yusuke Samezawa, Yosuke Ochi, Shun-ichi Wada, Hidehito Urata. Syntheses of prodrug-type phosphotriester oligonucleotides responsive to intracellular reducing environment for improvement of cell membrane permeability and nuclease resistance. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017. 27. 14. 3135-3138

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MISC (19)：

大庭龍之介, 三橋久子, 越智洋輔, 渕崎晶弘, 林智也, 堀江芳典, 河村朋子, 田中光信, 瀧原義弘, 下垣一成, et al. 洗浄血小板の調製に向けた新規製造方法の検討. 血液事業. 2023. 46. 1
三橋久子, 越智洋輔, 渕崎晶弘, 大庭龍之介, 林智也, 堀江芳典, 河村朋子, 田中光信, 瀧原義宏, 下垣一成, et al. 洗浄血小板の調製に向けた新規製造方法の検討. 血液事業. 2022. 45. 2
林淳祐, 船木涼平, 越智洋輔, 和田俊一, 浦田秀仁. 細胞内還元環境に応答する直鎖ジスルフィド修飾を施したプロドラッグ型リン酸トリエステル(PTE)核酸の合成. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. ROMBUNNO.21PO-pm035
越智洋輔, 林淳祐, 森田康之, 西垣美沙, 和田俊一, 浦田秀仁. 還元環境に応答するプロドラッグ型RNAの配列拡張を指向した合成研究. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. ROMBUNNO.21PO-pm086
林淳祐, 西垣美沙, 越智洋輔, 和田俊一, 和田郁人, 和田郁人, 小比賀聡, 斯波真理子, 浦田秀仁. 細胞内還元環境により活性化するプロドラッグ型2’-O-methyldithiomethyl-siRNAの効率的RNAi効果~非プロドラッグ型2’-O-methyl siRNAのRNAi活性との比較~. 日本核酸医薬学会年会講演要旨集. 2018. 4th. 75

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Lectures and oral presentations (12)：

洗浄血小板の調製に向けた新規製造方法の検討
(第70回日本輸血・細胞治療学会学術総会 2022)
Properties of reducing-environment-responsive prodrug-type phosphate-modified oligonucleotides for development of oligonucleotide therapeutics
(The 46th International Symposium on Nucleic Acids Chemistry 2019)
Syntheses and properties of reducing environment responsive prodrug-type oligonucleotides bearing cyclic and linear disulfide moieties
(Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry 2019 2019)
General synthesis and knockdown activity of prodrug-type 2'-O-methyldithiomethyl oligonucleotide
(The 45th International Symposium on Nucleic Acids Chemistry 2018 2018)
細胞内還元環境により天然型核酸へと変換されるプロドラッグ型PTE核酸の開発ー直鎖ジスルフィド修飾による還元環境応答性の評価ー
(第68回日本薬学会近畿支部総会・大会 2018)

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Professional career (1)：

博士(薬科学) (大阪薬科大学)

Association Membership(s) (4)：

The Japan Society of Transfusion Medicine and Cell Therapy , 日本血液事業学会 , 日本核酸化学会 , THE PHARMACEUTICAL SOCIETY OF JAPAN

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