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Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA
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About Hayashi Junsuke
About Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
About Nishigaki Misa
About Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
About Ochi Yosuke
About Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
About Wada Shun-ichi
About Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
About Wada Fumito
About Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
About Wada Fumito
About National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan
About Nakagawa Osamu
About Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
About Obika Satoshi
About Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
About Harada-Shiba Mariko
About National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan
About Urata Hidehito
About Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
Material：
About Bioorganic & Medicinal Chemistry Letters
Volume： 28 Issue： 12 Page： 2171-2174 Publication year： 2018
JST Material Number： W0248A ISSN： 0960-894X Document type： Article
Article type： 短報 Country of issue： Netherlands (NLD) Language： ENGLISH (EN)
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Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
About nuclease
About RNA
About Serum
About Digestion
About therapy
About siRNA
About prodrug
About reduction environment
About nucleotide
About Gene Silencing
About cleavage reaction
About RNA-Induced Silencing Complex
About Prodrug-type RNA
About Disulfide-bond cleavage
About Reducing environment
About 2′-O-modified siRNA
Category name(code) classified by JST.
About Nucleosides,nucleotides
About Synthesis of drugs
Keywords automatically extracted from the title.
About プロドラッグ
About siRNA
About 遺伝子サイレンシング
About 活性
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