Hideo Negishi

Affiliation and department：
Job title：特任講師

Research field (1)： Immunology

Research keywords (5)：創薬 , 免疫 , 自然免疫 , 内在性RNA , パターン認識受容体

Research theme for competitive and other funds (8)：

2021 - 2025 内在性炎症性RNAの実態と免疫疾患発症・増悪機構の解明
2018 - 2021 Analysis of endogenous RNA related to autoimmune diseases
2015 - 2020 Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
2015 - 2016 自己由来分子による炎症・免疫応答系の制御機構の解明
2013 - 2015 新規低分子化合物を用いたがん抑制機構の解析

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Papers (35)：

Junko Nishio, Hideo Negishi, Mika Yasui-Kato, Shoji Miki, Kazuhiko Miyanaga, Kotaro Aoki, Takuma Mizusawa, Masami Ueno, Akira Ainai, Masafumi Muratani, et al. Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis. Scientific reports. 2021. 11. 1. 20231-20231
Hideo Negishi, Nobuyasu Endo, Yuki Nakajima, Tatsuaki Nishiyama, Yuichiro Tabunoki, Junko Nishio, Ryuji Koshiba, Atsushi Matsuda, Kosuke Matsuki, Tomohisa Okamura, et al. Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2019. 116. 47. 23653-23661
Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H. Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways. Cancer science. 2018. 109. 9. 2687-2696
Hideyuki Yanai, Shiho Chiba, Sho Hangai, Kohei Kometani, Asuka Inoue, Yoshitaka Kimura, Takaya Abe, Hiroshi Kiyonari, Junko Nishio, Naoko Taguchi-Atarashi, et al. Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proceedings of the National Academy of Sciences of the United States of America. 2018. 115. 20. 5253-5258
Hana Sarashina-Kida, Hideo Negishi, Junko Nishio, Wataru Suda, Yuki Nakajima, Mika Yasui-Kato, Keiko Iwaisako, Sujin Kang, Nobuyasu Endo, Hideyuki Yanai, et al. Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017. 114. 38. 10178-10183

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MISC (9)：

根岸英雄, 和田雄佑, 石井健. ウイルス感染におけるZBP1とPANoptosis-ZBP1 and PANoptosis in viral infection. 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会編. 2022. 77. 6. 758-763
根岸英雄, 石井健. 【細胞死と炎症】細胞内分子がひき起こす免疫反応. 臨床免疫・アレルギー科. 2020. 74. 6. 550-557
Hideo Negishi, Nobuyasu Endo, Yuki Nakajima, Tatsuaki Nishiyama, Junko Nishio, Takeshi Doi, Tadatsugu Taniguchi. Identification of endogenous nucleic acid as a cause of inflammation and potential therapeutic target of inflammatory diseases. CYTOKINE. 2017. 100. 141-142
Yoshitaka Kimura, Asuka Inoue, Sho Hangai, Shinobu Saijo, Hideo Negishi, Junko Nishio, Sho Yamasaki, Yoichiro Iwakura, Hideyuki Yanai, Tadatsugu Taniguchi. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. CYTOKINE. 2017. 100. 56-56
安井美加, 根岸英雄, 西尾純子, 三木祥治, 中島由希, 丹治保典, 宮永一彦, 黒田誠, 関塚剛, 長谷川秀樹, et al. 腸内に常在する新規バクテリオファージの同定および解析. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.1P-1092 (WEB ONLY)

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Patents (2)：

非公開
1. Toll様受容体3遺伝子導入マウスから樹立した細胞株並びにToll様受容体3のアゴニスト又はアンタゴニストのスクリーニング方法。

Books (2)：

抗ウイルス応答と抗細菌応答における自然免疫シグナルのクロストーク
感染•炎症•免疫 2013
IRFファミリー転写因子によるTLRシグナルの正と負の制御機構
エンドトキシン研究会 2006

Lectures and oral presentations (4)：

公益財団法人日本リウマチ財団
(リウマチ月間リウマチ講演会 2018)
医薬基盤研
(第12回霊長類医科学フォーラム 2016)
国立感染症研究所
(ウイルス第二部合同セミナー 2012)
北海道大学遺伝子病制御研究所
(第7回研究交流セミナー 2009)

Awards (2)：

2018 - ポスター賞第一位
2018 - Japan Rheumatism Foundation 三浦記念リウマチ学術研究賞

Association Membership(s) (5)：

THE JAPANESE SOCIETY FOR VIROLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本骨免疫学会 , Japanese Society of Interferon and Cytokine Research , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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