Art

J-GLOBAL ID：202002217990607038   Reference number：20A2270212

Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock

哺乳類細胞で発現したモノカルボン酸輸送体9を介した尿酸取込の証拠と熱ショックによるその増強

Author (19)： Otani Naoyuki (Department of Clinical Pharmacology and Therapeutics, Oita University Faculty of Medicine) ,  Kurata Yasutaka (Department of Physiology II, Kanazawa Medical University) ,  Maharani Nani (Department of Pharmacology and Therapy, Faculty of Medicine Diponegoro University) ,  Kuwabara Masanari (Intensive Care Unit and Department of Cardiology, Toranomon Hospital) ,  Ikeda Nobuhito (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science) ,  Notsu Tomomi (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science) ,  Li Peili (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science) ,  Miake Junichiro (Department of Pharmacology, Tottori University Faculty of Medicine) ,  Yoshida Akio (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science) ,  Sakaguchi Hiromi (Department of Radiology, Tottori University Faculty of Medicine) ,  Higaki Katsumi (Division of Functional Genomics, Tottori University Research Center for Bioscience and Technology) ,  Nakasone Naoe (Department of Biological Regulation, Tottori University Faculty of Medicine) ,  Tsuneto Motokazu (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science) ,  Shirayoshi Yasuaki (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science) ,  Ouchi Motoshi (Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine) ,  Ninomiya Haruaki (Department of Biological Regulation, Tottori University Faculty of Medicine) ,  Yamamoto Kazuhiro (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine) ,  Anzai Naohiko (Department of Pharmacology, Chiba University Graduate School of Medicine) ,  Hisatome Ichiro (Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science)
Material： Circulation Reports (Web)
Volume： 2  Issue： 8  Page： 425-432(J-STAGE)  Publication year： 2020 
JST Material Number： U1625A  ISSN： 2434-0790  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： HEK293 cell ,...
Semi thesaurus term： proteasomal degradation ,...

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Author keywords (5)： Heat shock ,  Heat shock protein 70 (HSP70) ,  Hyperuricemia ,  Monocarboxylate transporter 9 ,  Urate uptake

JST classification (2)： Basic medicine on urogenital system  (GM01020T) ,  Transport of cell membrane  (EF04020R)

Substance index (1)： Uric Acid

Reference (34)：

• 1. Sugihara S, Hisatome I, Kuwabara M, Niwa K, Maharani N, Kato M, et al. Depletion of uric acid due to SLC22A12 (URAT1) loss-of-function mutation causes endothelial dysfunction in hypouricemia. Circ J 2015; 79: 1125-1132.
• 2. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis. Proc Natl Acad Sci USA 1981; 78: 6858-6862.
• 3. Waring WS, McKnight JA, Webb DJ, Maxwell SR. Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers. Diabetes 2006; 55: 3127-3132.
• 4. Ichida K, Hosoyamada M, Hisatome I, Enomoto A, Hikita M, Endou H, et al. Clinical and molecular analysis of patients with renal hypouricemia in Japan: Influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 2004; 15: 164-173.
• 5. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417: 447-452.

Terms in the title (8)： 哺乳類細胞 ,  発現 ,  モノカルボン酸輸送体 ,  尿酸 ,  取込 ,  証拠 ,  熱ショック ,  増強